Xenos E S, Khan F, Nery J, Romero R, Mocros J, Tzakis A
Department of Liver/GI Transplantation, University of Miami, Jackson Memorial Hospital, FL 33101, USA.
Transpl Int. 1999;12(1):63-7. doi: 10.1007/s001470050186.
Scarcity of size-matched grafts continues to be a major limiting factor for liver and combined liver/intestinal transplants in the pediatric population. It is reported that 29% of pediatric patients listed for hepatic transplantation die while waiting for a donor. The reported mortality of pediatric patients awaiting intestinal transplantation is about 40%. We report on a technique of segmental liver and intestinal transplantation in a child. To our knowledge, this is the first report of a combined split liver-intestinal transplantation. We used a cadaveric donor, but the technique can also be performed with a live donor. The adult recipient of one segment of the liver was discharged home without complications. The child who received the combined liver intestinal graft developed intestinal perforation and severe rejection and died. If this technique is applied successfully, the adverse effects and mortality of a long pretransplant waiting period in pediatric patients may be avoided.
在儿科人群中,大小匹配的移植物稀缺仍然是肝脏移植以及肝/肠联合移植的主要限制因素。据报道,29%列入肝移植名单的儿科患者在等待供体期间死亡。等待肠移植的儿科患者报告死亡率约为40%。我们报告了一名儿童的节段性肝肠移植技术。据我们所知,这是首例联合劈裂肝-肠移植的报告。我们使用了一名尸体供体,但该技术也可使用活体供体进行。接受肝脏其中一段的成年受者无并发症出院。接受肝肠联合移植物的儿童发生了肠穿孔和严重排斥反应并死亡。如果该技术成功应用,或许可以避免儿科患者移植前漫长等待期的不良影响和死亡率。