Barrett M P, Mottram J C, Coombs G H
Division of Infection & Immunity, University of Glasgow, UK.
Trends Microbiol. 1999 Feb;7(2):82-8. doi: 10.1016/s0966-842x(98)01433-4.
The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation.
锥虫的生物化学独特之处使合理药物设计成为一种有吸引力的方法，但必须谨慎选择靶点。基因操作提供了一种宝贵手段，可模拟因治疗干预导致的功能丧失，但在根据此类数据进行靶点验证时必须谨慎行事。
