Berggren U, Tallstedt L, Ahlenius S, Engel J
Psychopharmacology (Berl). 1978 Sep 15;59(1):41-5. doi: 10.1007/BF00428028.
A behavioural study was performed to investigate how lithium interacts with monoamine mechanisms. Acute lithium pretreatment partially antagonized amphetamine-induced locomotor stimulation in mice. A rather small dose of L-dopa, which had no stimulant effect on locomotor activity of its own, caused a dose-dependent antagonism of the lithium-induced suppression of the amphetamine-induced locomotor stimulation. Additionally, acute lithium pretreatment had no effect on the apomorphine-clonidine-induced locomotor stimulation after elimination of presynaptic activity by means of pretreatment with reserpine and alpha-MT. Our interpretation of these results is that the inhibitory effect on amphetamine-induced locomotor stimulation is likely to be mediated via presynaptic mechanisms (i.e., decreased release of catecholamines or inhibition of catecholamine synthesis or a combination of both mechanisms) and, further, lithium seems to have no effect at or beyond the catecholamine receptors. However, the possibility that lithium may increase the activity in neuronal systems antagonizing the catecholamine neurons cannot be excluded.
进行了一项行为学研究，以探究锂如何与单胺机制相互作用。急性锂预处理可部分拮抗苯丙胺对小鼠的运动刺激作用。相当小剂量的左旋多巴本身对运动活性没有刺激作用，但却能剂量依赖性地拮抗锂诱导的对苯丙胺诱导的运动刺激的抑制作用。此外，在用利血平和α-甲基酪氨酸预处理消除突触前活性后，急性锂预处理对阿扑吗啡-可乐定诱导的运动刺激没有影响。我们对这些结果的解释是，对苯丙胺诱导的运动刺激的抑制作用可能是通过突触前机制介导的（即儿茶酚胺释放减少或儿茶酚胺合成受抑制或两种机制共同作用），而且，锂似乎在儿茶酚胺受体处或受体之后没有作用。然而，锂可能会增加拮抗儿茶酚胺能神经元的神经功能系统活性这一可能性也不能排除。
