Rotun S S, McMath V, Schoonmaker D J, Maupin P S, Tenover F C, Hill B C, Ackman D M
United Hospital Medical Center (UHMC), Port Chester, New York, USA.
Emerg Infect Dis. 1999 Jan-Feb;5(1):147-9. doi: 10.3201/eid0501.990118.
A Staphylococcus aureus isolate with reduced susceptibility to vancomycin was obtained from a dialysis patient with a fatal case of bacteremia. Comparison of the isolate with two methicillin-resistant S. aureus (MRSA) isolated obtained from the same patient 4 months earlier suggests that the S. aureus with reduced susceptibility to vancomycin emerged from the MRSA strain with which the patient was infected. Atypical phenotypic characteristics, including weak or negative latex-agglutination test results, weak or negative-slide coagulase test results, heterogeneous morphologic features, slow rate of growth, and vancomycin susceptibility (by disk diffusion test) were observed.
从一名患有致命菌血症的透析患者身上分离出一株对万古霉素敏感性降低的金黄色葡萄球菌。将该分离株与4个月前从同一患者身上分离出的两株耐甲氧西林金黄色葡萄球菌（MRSA）进行比较，结果表明，对万古霉素敏感性降低的金黄色葡萄球菌源自该患者感染的MRSA菌株。观察到该菌株具有非典型的表型特征，包括乳胶凝集试验结果弱阳性或阴性、玻片凝固酶试验结果弱阳性或阴性、形态特征异质性、生长速度缓慢以及（通过纸片扩散试验测定的）万古霉素敏感性。
