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耐甲氧西林金黄色葡萄球菌长期菌血症期间万古霉素和达托霉素敏感性降低

Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus.

作者信息

Bennett Jason W, Murray Clinton K, Holmes Robert L, Patterson Jan E, Jorgensen James H

机构信息

Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.

出版信息

Diagn Microbiol Infect Dis. 2008 Apr;60(4):437-40. doi: 10.1016/j.diagmicrobio.2007.11.002. Epub 2007 Dec 21.

DOI:10.1016/j.diagmicrobio.2007.11.002
PMID:18096352
Abstract

An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.

摘要

一名患有耐甲氧西林金黄色葡萄球菌（MRSA）菌血症的老年患者先后接受了万古霉素加利福平，然后是达托霉素加庆大霉素的治疗。在治疗期间，MRSA菌株对万古霉素（MIC增加和耐受性）、达托霉素和庆大霉素的敏感性降低，并对利福平产生了耐药性。

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