Teixeira M, Couloigner V, Loiseau A, Hulin P, Sterkers O, Planelles G, Ferrary E
INSERM U.426, Faculté Xavier Bichat, Université Paris 7, France.
Hear Res. 1999 Feb;128(1-2):45-50. doi: 10.1016/s0378-5955(98)00197-x.
The transepithelial potential in the endolymphatic sac (ESP) was recorded up to 60 min after apical injection of ouabain, bumetanide, quinine, barium, tetraethylammonium, and 4-aminopyridine. After control injection, ESP decreased by 74% and completely recovered at 30 min. After ouabain, barium, or quinine injection, the ESP time course was similar to that in the control group. After bumetanide, tetraethylammonium, or 4-aminopyridine injection, complete recovery was only observed at 60 min. These results suggest that apical K+ conductance and Na-K-2Cl cotransporter could be involved in the genesis of ESP.
在内淋巴囊（ESP）中，在向顶端注射哇巴因、布美他尼、奎宁、钡、四乙铵和4-氨基吡啶后，记录跨上皮电位长达60分钟。对照注射后，ESP下降了74%，并在30分钟时完全恢复。注射哇巴因、钡或奎宁后，ESP的时间进程与对照组相似。注射布美他尼、四乙铵或4-氨基吡啶后，仅在60分钟时观察到完全恢复。这些结果表明顶端K+电导和Na-K-2Cl共转运体可能参与ESP的发生。
