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通过向输精管注射化学药剂诱导雄性大鼠不育。

Sterility induced in male rats by injection of chemical agents into the vas deferens.

作者信息

Raman G, Purandare T V, Munshi S R

出版信息

Andrologia. 1976;8(4):321-5. doi: 10.1111/j.1439-0272.1976.tb01663.x.

DOI:10.1111/j.1439-0272.1976.tb01663.x
PMID:1008263
Abstract

Changes in the histopathology of the testes with the epididymis were studied 3 months and 6 months after vasocclusion either with ethanol urea mixture or ethanol alone in male rats. A gradual decrease in the fertility of treated animals was observed. The epididymis showed tubules with sperm granuloma and the testis showed empty tubules with Leydig cell hyperplasia in the urea-ethanol treated animals.

摘要

在雄性大鼠中,研究了用乙醇尿素混合物或单独用乙醇进行输精管阻塞后3个月和6个月时睾丸与附睾的组织病理学变化。观察到处理组动物的生育能力逐渐下降。在尿素 - 乙醇处理的动物中,附睾显示有精子肉芽肿的小管,睾丸显示有空的小管和间质细胞增生。

相似文献

1
Sterility induced in male rats by injection of chemical agents into the vas deferens.通过向输精管注射化学药剂诱导雄性大鼠不育。
Andrologia. 1976;8(4):321-5. doi: 10.1111/j.1439-0272.1976.tb01663.x.
2
Neonatal estrogen treatment with β-estradiol 17-cypionate induces in post-pubertal mice inflammation in the ductuli efferentes, epididymis, and vas deferens, but not in the testis, provoking obstructive azoospermia.用17-环戊丙酸雌二醇进行新生儿雌激素治疗,可在青春期后小鼠的输出小管、附睾和输精管中引发炎症,但在睾丸中不会引发炎症,从而导致梗阻性无精子症。
Med Mol Morphol. 2014 Mar;47(1):21-30. doi: 10.1007/s00795-013-0034-z. Epub 2013 Mar 20.
3
Sterility in male animals induced by injection of chemical agents into the vas deferens.通过向输精管注射化学药剂诱导雄性动物不育。
Fertil Steril. 1973 Nov;24(11):884-90.
4
The effects of ligation of vas deferens, corpus epididymidis and vasa efferentia on the testicular function in rats.输精管、附睾体和输出小管结扎对大鼠睾丸功能的影响。
Tohoku J Exp Med. 1976 Nov;120(3):251-7. doi: 10.1620/tjem.120.251.
5
Post-vasectomy impairment of transepithelial water reabsorption in the initial segment of the epididymis.输精管结扎术后附睾起始段经上皮水重吸收功能受损。
Arch Androl. 1983 Dec;11(3):265-70. doi: 10.3109/01485018308987492.
6
The effects of chemical occlusion of vas deferens on the testicular function of dog: a preliminary study.
Acta Eur Fertil. 1975 Dec;6(4):348-53.
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Effects of a single ethanol injection into the vas deferens on the testicular function of rats.
Endokrinologie. 1976 Mar;67(1):8-13.
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Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.雄性生殖道中组成型活性Notch1的表达会导致输出小管异位生长和阻塞、附睾增生以及不育。
Dev Biol. 2006 Dec 15;300(2):497-511. doi: 10.1016/j.ydbio.2006.09.010. Epub 2006 Sep 14.
9
Studies on vasectomy.输精管切除术研究。
Taehan Uihak Hyophoe Chi. 1967 Dec;10(12):51-71.
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Alteration of epididymal function and its relation to maturation of spermatozoa.附睾功能的改变及其与精子成熟的关系。
Andrologia. 1974;6(1):35-44. doi: 10.1111/j.1439-0272.1974.tb01589.x.

引用本文的文献

1
Male animal sterilization: history, current practices, and potential methods for replacing castration.雄性动物绝育:历史、当前做法以及替代去势的潜在方法。
Front Vet Sci. 2024 Jul 3;11:1409386. doi: 10.3389/fvets.2024.1409386. eCollection 2024.