Role of NMDA glutamate receptors in regulating D2 dopamine-dependent Fos induction in the rat striatopallidal pathway.
作者信息
Pollack A E, Bird J L, Lambert E B, Florin Z P, Castellar V L
机构信息
Department of Psychology, Box 1853, Brown University, Providence, RI 02912, USA.
出版信息
Brain Res. 1999 Feb 13;818(2):543-7. doi: 10.1016/s0006-8993(98)01297-9.
Abstract
Acute administration of reserpine induces Fos expression in striatopallidal neurons, an effect blocked by pretreatment with the D2 dopamine agonist quinpirole. Pretreatment with the NMDA antagonists (+)MK-801 or CPP attenuated reserpine-mediated striatal Fos induction whereas pretreatment with ketamine or the inactive isomer (-)MK-801 did not. These results support a role of NMDA glutamate receptors in regulating the activity of the striatopallidal pathway.
摘要
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