Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival.
作者信息
Rastellini C, Salam A, Kuddus R, Aitouche A, Subbotin V, Braun M, Leach R, Peach R, Fung J J, Starzl T E, Rao A S
机构信息
Section of Cellular Transplantation, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania, USA.
出版信息
Transplant Proc. 1999 Feb-Mar;31(1-2):1242-3. doi: 10.1016/s0041-1345(98)01979-4.
Abstract
摘要
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Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival.重组人CTLA4-Ig和抗CD40L单克隆抗体对T细胞激活的抑制作用可使胰岛移植长期存活。
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本文引用的文献
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Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.人CTLA4Ig在同种异体胰岛移植非人灵长类动物模型中的免疫抑制作用。
J Immunol. 1997 Dec 1;159(11):5187-91.
2
Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody.通过联合使用CTLA4-Ig和抗CD40配体单克隆抗体预防小鼠主动脉同种异体移植中的慢性排斥反应。
Transplantation. 1997 Dec 27;64(12):1838-43. doi: 10.1097/00007890-199712270-00035.
3
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.CTLA4免疫球蛋白和抗CD40配体可预防灵长类动物的肾移植排斥反应。
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8789-94. doi: 10.1073/pnas.94.16.8789.
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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.阻断CD40和CD28信号通路后皮肤和心脏同种异体移植的长期存活
Nature. 1996 May 30;381(6581):434-8. doi: 10.1038/381434a0.
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