Aouifi A, Piriou V, Bastien O, Joseph P, Blanc P, Chiari P, Diab C, Villard J, Lehot J J
Service d'Anesthésie-Réanimation, Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France.
Can J Anaesth. 1999 Feb;46(2):114-21. doi: 10.1007/BF03012544.
To determine the incidence, circumstances of occurrence and evolution of gastrointestinal complications after cardiac surgery with extracorporeal circulation (ECC).
Retrospective chart study of gastrointestinal complications in 6.281 patients undergoing ECC between january 1994 and December 1997.
Sixty patients developed 68 gastrointestinal complications (1%). Complications included: upper gastrointestinal bleeding (n = 23), intestinal ischemia (n = 19), cholecystitis (n = 7), pancreatitis (n = 6), and paralytic ileus (n = 16). The incidence of these complications was low after coronary artery (0.4%) or valvular surgery (0.8%) and high after cardiac transplantation (6%) and after surgery for acute aortic dissection (9%). Compared with a control population, patients with gastrointestinal complication had a higher Parsonnet score (29 +/- 15 vs 13 +/- 12 points; P = 0.002), were more frequently operated upon as an emergency (40/60, 66% vs 1120/6221, 18%; P = 0.01), underwent ECC of longer duration (114 +/- 66 vs 74 +/- 42 min; P = 0.01), and presented more frequently with low cardiac output after surgery (45/60, 75% vs 435/6221, 7%; P = 0.001). The mortality rate after gastrointestinal complications was 52%. The major factor associated with mortality was the occurrence of sepsis (OR = 38.7). Other factors were: renal failure (OR = 7.9), age > 75 yr (OR = 3.5), mechanical ventilation for more than seven days (OR = 2.7), associated cerebral damage (OR = 3.9).
Gastrointestinal complications after ECC occur in high risk surgical patients. These complications are frequently associated with other complications leading to a high mortality rate.
确定体外循环心脏手术后胃肠道并发症的发生率、发生情况及演变过程。
对1994年1月至1997年12月期间接受体外循环手术的6281例患者的胃肠道并发症进行回顾性图表研究。
60例患者发生了68例胃肠道并发症(1%)。并发症包括:上消化道出血(23例)、肠缺血(19例)、胆囊炎(7例)、胰腺炎(6例)和麻痹性肠梗阻(16例)。这些并发症在冠状动脉手术后(0.4%)或瓣膜手术后(0.8%)发生率较低,而在心脏移植后(6%)和急性主动脉夹层手术后(9%)发生率较高。与对照组相比,发生胃肠道并发症的患者Parsonnet评分更高(29±15分对13±12分;P=0.002),更常作为急诊手术(40/60,66%对1120/6221,18%;P=0.01),体外循环时间更长(114±66分钟对74±42分钟;P=0.01),术后更常出现低心排血量(45/60,75%对435/6221,7%;P=0.001)。胃肠道并发症后的死亡率为52%。与死亡率相关的主要因素是脓毒症的发生(OR=38.7)。其他因素包括:肾衰竭(OR=7.9)、年龄>75岁(OR=3.5)、机械通气超过7天(OR=2.7)、合并脑损伤(OR=3.9)。
体外循环心脏手术后胃肠道并发症发生在高危手术患者中。这些并发症常与其他并发症相关,导致高死亡率。