Fujino S, Matsunari I, Saga T, Okazaki H, Haraki T, Aoyama T, Hirai J, Doishita K, Takekoshi N
Department of Cardiology, Fukui Prefectural Hospital, Japan.
Jpn Circ J. 1999 Jan;63(1):64-7. doi: 10.1253/jcj.63.64.
A 68-year-old man suffering from chronic heart failure due to coronary artery disease (CAD) underwent rest technetium-99m (99mTc)-tetrofosmin and thallium-201 (201Tl) with reinjection studies, but died thereafter. The heart was removed and sectioned into short-axis slices and examined by gross and microscopic pathologic methods. A close correlation between the amount of residual cardiomyocytes and the level of regional tracer activity in the left ventricular wall was obtained for redistribution 201Tl, reinjection 201Tl and rest 99mTc tetrofosmin images. The correlation coefficients were r=0.901 for the 201Tl redistribution images, r=0.913 for the 201Tl reinjection images and r=0.917 for the rest 99mTc-tetrofosmin images. This case report provides further evidence of the validity of SPECT tetrofosmin imaging for the determination of myocardial viability in CAD.
一名68岁因冠状动脉疾病（CAD）患有慢性心力衰竭的男性接受了静息状态下的锝-99m（99mTc）-替曲膦和铊-201（201Tl）再注射研究，但随后死亡。心脏被取出并切成短轴切片，通过大体和显微镜病理方法进行检查。对于201Tl再分布、201Tl再注射和静息99mTc替曲膦图像，在左心室壁中残余心肌细胞数量与局部示踪剂活性水平之间获得了密切相关性。201Tl再分布图像的相关系数为r = 0.901，201Tl再注射图像的相关系数为r = 0.913，静息99mTc-替曲膦图像的相关系数为r = 0.917。本病例报告为单光子发射计算机断层扫描（SPECT）替曲膦成像在CAD中确定心肌存活能力的有效性提供了进一步证据。
