Yamamoto M, Tajima F, Okawa H, Mizushima T, Umezu Y, Ogata H
Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Arch Phys Med Rehabil. 1999 Mar;80(3):288-93. doi: 10.1016/s0003-9993(99)90139-9.
To compare the pressor response to static exercise in subjects with cervical spinal cord injury (SCI) at the C6 to C8 level with that in able-bodied control subjects. In these SCI subjects, the descending supraspinal sympathetic neurons and afferent pathways from the contracting muscles to peripheral vessels via the medullary cardiovascular center are damaged.
Mean arterial blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, renin activity, vasopressin, aldosterone, and human atrial natriuretic peptide were measured during a 2-minute period of sustained contraction of elbow flexor group muscle in 7 SCI subjects and 7 age-matched able-bodied control subjects.
Static exercise resulted in a significant increase in mean blood pressure (p<.05) in both SCI subjects (pre-exercise. 74.7+/-2.2 mm Hg; static exercise, 81.9+/-4.1 mm Hg) and control subjects (pre-exercise, 101.0+/-4.2 mm Hg; static exercise, 117.0+/-4.9 mm Hg). In SCI subjects, there was no change in heart rate during exercise, whereas in control subjects heart rate increased during exercise (p<.05) (pre-exercise, 8.7+/-3.8 beats/min: static exercise, 76.0+/-3.1 beats/min). There were no significant changes in the hormone levels in the SCI subjects throughout the experiment.
The significant increase in mean blood pressure observed in the present study indicates the presence of peripheral control from muscle receptors and evoked pressor response during static exercise in SCI subjects.
比较颈6至颈8水平的颈脊髓损伤（SCI）患者与健康对照者在静态运动时的升压反应。在这些SCI患者中，下行的脊髓上交感神经元以及从收缩肌肉经延髓心血管中枢至外周血管的传入通路受损。
在7名SCI患者和7名年龄匹配的健康对照者的肘屈肌群肌肉持续收缩2分钟期间，测量平均动脉血压、心率以及去甲肾上腺素、肾上腺素、肾素活性、血管加压素、醛固酮和人心房利钠肽的血浆浓度。
静态运动使SCI患者（运动前，74.7±2.2 mmHg；静态运动时，81.9±4.1 mmHg）和对照者（运动前，101.0±4.2 mmHg；静态运动时，117.0±4.9 mmHg）的平均血压均显著升高（p<0.05）。在SCI患者中，运动期间心率无变化，而在对照者中运动期间心率增加（p<0.05）（运动前，8.7±3.8次/分钟；静态运动时，76.0±3.1次/分钟）。在整个实验过程中，SCI患者的激素水平无显著变化。
本研究中观察到的平均血压显著升高表明，SCI患者在静态运动期间存在来自肌肉受体的外周控制和诱发的升压反应。
