Querfeld U, Döpper S, Gradehand A, Kiencke P, Wahn F, Zeisel H J
Department of Pediatrics, University of Cologne, Germany.
J Clin Endocrinol Metab. 1999 Mar;84(3):967-70. doi: 10.1210/jcem.84.3.5516.
Treatment with recombinant human GH (rhGH), alone or in combination with the anabolic steroid oxandrolone (OX), has been recommended for girls with Turner's syndrome to improve final height. Several cardiovascular risk factors have been described in patients with Turner's syndrome, but the effect of therapy with rhGH and OX on lipoprotein(a) [Lp(a)] has not been investigated. Lp(a) serum levels and apolipoprotein(a) phenotypes were determined in 46 girls with Turners syndrome (aged 6-15 yr) during treatment with different combinations of rhGH and OX for 24-36 months (median, 27 months). Lp(a) serum levels showed little variation during 30 months of treatment in all treatment groups. Lp(a) levels showed no significant change in 25 patients receiving only rhGH and in 21 patients receiving rhGH and OX in combination. Treatment effects were independent of apolipoprotein(a) phenotypes and were not influenced by pubertal status. These data indicate that long term administration of rhGH has no significant impact on serum Lp(a) levels in girls with Turner's syndrome.
对于特纳综合征女孩，推荐使用重组人生长激素（rhGH）单独治疗或与合成代谢类固醇氧雄龙（OX）联合治疗，以提高最终身高。特纳综合征患者存在多种心血管危险因素，但rhGH和OX治疗对脂蛋白（a）[Lp（a）]的影响尚未得到研究。对46名特纳综合征女孩（年龄6 - 15岁）在接受rhGH和OX不同组合治疗24 - 36个月（中位数为27个月）期间测定了Lp（a）血清水平和载脂蛋白（a）表型。在所有治疗组中，治疗30个月期间Lp（a）血清水平变化不大。25名单独接受rhGH治疗的患者和21名接受rhGH与OX联合治疗的患者的Lp（a）水平均无显著变化。治疗效果与载脂蛋白（a）表型无关，且不受青春期状态影响。这些数据表明，长期给予rhGH对特纳综合征女孩的血清Lp（a）水平无显著影响。
