血管生成的新血流动力学方法：彩色和脉冲多普勒超声检查
New hemodynamic approach to angiogenesis: color and pulsed Doppler ultrasonography.
作者信息
Lassau N, Paturel-Asselin C, Guinebretiere J M, Leclère J, Koscielny S, Roche A, Chouaib S, Peronneau P
机构信息
Department of Medical Imaging, Institut Gustave Roussy, Villejuif, France.
出版信息
Invest Radiol. 1999 Mar;34(3):194-8. doi: 10.1097/00004424-199903000-00007.
RATIONALE AND OBJECTIVES
To determine the capacity of color and spectral Doppler ultrasonography (US) to quantify angiogenesis in vivo and to characterize low-resistance intratumor blood flow.
METHODS
Thirty-two tumors, xenografted into mice, were studied with Doppler US. The number of intratumor vessels visualized with color Doppler US was compared with the density of microvessels and the number of vessels >100 microm determined by histologic examination. The resistance index and the peak systolic velocities were evaluated.
RESULTS
The number of intratumor vessels visualized by color Doppler US was correlated with the number of vessels >100 microm (P<0.001) determined histologically. When vessel density was >30, intratumor vessels were always detected by color Dopper US. The resistance index and peak systolic velocities were significantly lower in intratumor than in peritumor vessels.
CONCLUSIONS
Color Doppler US evaluated tumor angiogenesis accurately. Spectral analysis confirmed the low resistance of intratumor blood flow.
原理与目的
确定彩色及频谱多普勒超声（US）在体内定量血管生成以及表征肿瘤内低阻力血流的能力。
方法
对32个移植到小鼠体内的肿瘤进行多普勒超声研究。将彩色多普勒超声显示的肿瘤内血管数量与微血管密度以及组织学检查确定的直径>100微米的血管数量进行比较。评估阻力指数和收缩期峰值速度。
结果
彩色多普勒超声显示的肿瘤内血管数量与组织学确定的直径>100微米的血管数量相关（P<0.001）。当血管密度>30时，彩色多普勒超声总能检测到肿瘤内血管。肿瘤内血管的阻力指数和收缩期峰值速度显著低于肿瘤周围血管。
结论
彩色多普勒超声能准确评估肿瘤血管生成。频谱分析证实肿瘤内血流阻力较低。
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