Sabatier J, Gilard V, Malet-Martino M, Ranjeva J P, Terral C, Breil S, Delisle M B, Manelfe C, Tremoulet M, Berry I
Department of Neurosurgery, University Hospital Purpan, France.
Invest Radiol. 1999 Mar;34(3):230-5. doi: 10.1097/00004424-199903000-00013.
The authors sought to compare 1H magnetic resonance spectroscopy (MRS) spectra from extracts of low-grade and high-grade gliomas, especially with respect to the signals of choline-containing compounds.
Perchloric acid extracts of six high-grade and six low-grade gliomas were analyzed by 1H MRS at 9.4 Tesla.
The signals of glycerophosphocholine (GPC) at 3.23 ppm, phosphocholine (PC) at 3.22 ppm, and choline (Cho) at 3.21 ppm were identified in both types of tumors. The absolute concentrations of all Cho-containing compounds (GPC + PC + Cho) in high-grade and low-grade gliomas were significantly different. The relative contributions of each of the Cho-containing compounds to the total choline signal were also statistically different. For high-grade gliomas, the choline signal is composed of GPC, PC, and Cho in a well-balanced contribution, whereas in low-grade gliomas, the signal is largely due to GPC with a small involvement of PC and Cho.
The differences in the concentration and the repartition of Cho-containing compounds seem to be a marker of high-grade gliomas. They could also help to discriminate between high- and low-grade gliomas in some difficult cases, especially if there is histologic uncertainty between anaplastic astrocytomas and low-grade oligodendrogliomas.
作者试图比较低级别和高级别胶质瘤提取物的1H磁共振波谱（MRS），特别是关于含胆碱化合物的信号。
对6例高级别和6例低级别胶质瘤的高氯酸提取物在9.4特斯拉下进行1H MRS分析。
在两种类型的肿瘤中均鉴定出3.23 ppm处的甘油磷酸胆碱（GPC）、3.22 ppm处的磷酸胆碱（PC）和3.21 ppm处的胆碱（Cho）信号。高级别和低级别胶质瘤中所有含胆碱化合物（GPC + PC + Cho）的绝对浓度存在显著差异。每种含胆碱化合物对总胆碱信号的相对贡献也存在统计学差异。对于高级别胶质瘤，胆碱信号由GPC, PC和Cho贡献平衡组成，而在低级别胶质瘤中，信号主要归因于GPC，PC和Cho贡献较小。
含胆碱化合物的浓度和分布差异似乎是高级别胶质瘤的一个标志物。它们还可以在某些困难病例中帮助区分高级别和低级别胶质瘤，特别是在间变性星形细胞瘤和低级别少突胶质细胞瘤之间存在组织学不确定性的情况下。
