Jackson A H, Ferramola A M, Sancovich H A, Evans N, Matlin S A, Ryder D J, Smith S G
Ann Clin Res. 1976;8 Suppl 17:64-9.
In the course of our studies on intermediates in normal and abnormal metabolism of porphyrins we have synthesised a number of porphyrins related to uroporphyrin-III and compared them with materials isolated from natural sources. In the present paper we show that the corresponding porphyrinogens are all metabolised to protoporphyrin-IX by haemolysates of chicken erythrocytes, but at different rates. The results are discussed in relation to our conclusions concerning the preferred pathway of degradation of uro'gen-III to coproporphyrinogen-III, which indicate a clockwise sequence of decarboxylation reactions.
在我们对卟啉正常和异常代谢中间体的研究过程中，我们合成了一些与尿卟啉 -III 相关的卟啉，并将它们与从天然来源分离得到的物质进行了比较。在本文中，我们表明相应的卟啉原都能被鸡红细胞溶血产物代谢为原卟啉 -IX，但代谢速率不同。结合我们关于尿卟啉原 -III 降解为粪卟啉原 -III 的首选途径的结论对这些结果进行了讨论，该结论表明脱羧反应是按顺时针顺序进行的。
