Prentice H G, Caillot D, Dupont B, Menichetti F, Schuler U
Department of Haematology, Royal Free Hospital and School of Medicine, London,
Acta Haematol. 1999 Mar;101(1):56-62. doi: 10.1159/000040923.
Effective prevention, or treatment, of invasive fungal infection in the neutropenic patient has hitherto been unsatisfactory because of either an inadequate anti-fungal spectrum of the agent or important toxicity. Itraconazole is effective against a broad spectrum of the opportunistic pathogens seen in Europe and North America. Prior problems with absorption, e.g. in the marrow transplant recipient, have been overcome with the introduction of an oral solution and an i.v. preparation. The deliberations of an expert meeting held in June, 1998 include recommendations on which patient requires one of these new preparations based on clinical trials, the dose and route. Important drug interactions are also detailed.
由于抗真菌药物的抗菌谱不足或存在严重毒性，迄今为止，对中性粒细胞减少患者侵袭性真菌感染的有效预防或治疗并不理想。伊曲康唑对欧洲和北美的多种机会性病原体有效。以前存在的吸收问题，例如在骨髓移植受者中，随着口服溶液和静脉制剂的推出已得到解决。1998年6月召开的一次专家会议的讨论内容包括基于临床试验、剂量和给药途径，对哪些患者需要这些新制剂之一的建议。还详细介绍了重要的药物相互作用。
