Refaie A, Sobh M, Moustafa F, Bakr M A, El-Mekresh M, Farahat S, Ghoneim M A
Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Am J Nephrol. 1999;19(1):55-9. doi: 10.1159/000013426.
We studied the outcome of renal transplantation in 30 patients with primary focal-segmental glomerulosclerosis (FSGS) and in 30 controls in whom renal failure was secondary to nonglomerular renal diseases. All patients received living-related-donor kidneys, and the majority had one-haplotype HLA matching. Within the follow-up period, the mean serum creatinine values were significantly higher in FSGS recipients as compared with the control group (p = 0.02). However, the frequency of acute rejection episodes and the mean blood pressure values were not significantly different between the two groups. There was a tendency of a higher incidence of proteinuria among FSGS recipients in comparison with the controls. Moreover, nephrotic-range proteinuria occurred only in 3 recipients of the FSGS group. Recurrence of FSGS was morphologically documented in 2 recipients 7 and 18 months, respectively, after transplantation. It is concluded that FSGS as the primary disease has a negligible impact on the living-related-donor kidney transplantation in the Egyptian population. Therefore, this disease should not discourage transplantation for this group of patients.
我们研究了30例原发性局灶节段性肾小球硬化（FSGS）患者以及30例因非肾小球性肾病继发肾衰竭的对照患者的肾移植结果。所有患者均接受了亲属活体供肾，且大多数患者为单倍型HLA配型。在随访期内，FSGS受者的平均血清肌酐值显著高于对照组（p = 0.02）。然而，两组之间急性排斥反应的发生率和平均血压值并无显著差异。与对照组相比，FSGS受者中蛋白尿的发生率有升高趋势。此外，肾病范围的蛋白尿仅发生在FSGS组的3例受者中。分别在移植后7个月和18个月，有2例受者经形态学证实出现了FSGS复发。研究得出结论，在埃及人群中，原发性FSGS对亲属活体供肾移植的影响可忽略不计。因此，对于这类患者，这种疾病不应成为阻碍其进行移植的因素。
