Jedras M, Zakrzewska-Pniewska B, Wardyn K, Switalski M
Katedra i Klinika Chorób Wewnetrznych i Nefrologii Akademii Medycznej w Warszawie.
Pol Arch Med Wewn. 1998 Jun;99(6):452-61.
The aim of the study was to analyse the relationship between clinical and electrophysiological features of uremic neuropathy and age of patients, duration of kidney disease, renal failure and dialysis treatment. 51 patients with end-stage renal failure without diabetes were examined. Apart from a basic neurological examination, conduction velocities in the sural and tibial nerves were determined, and in order to assess the function of the autonomic nervous system, R-R interval variation and sympathetic skin response were tested. In majority of patients, symptoms and signs of sensorimotor neuropathy were found, and about 50% of them had dysautonomia. A negative correlation between age and R-R interval variation was observed. No relationship was found between neuropathy and the duration of nephropathy, duration of renal nor dialysis treatment.
该研究的目的是分析尿毒症神经病变的临床和电生理特征与患者年龄、肾脏疾病病程、肾衰竭及透析治疗之间的关系。对51例无糖尿病的终末期肾衰竭患者进行了检查。除了基本的神经系统检查外，还测定了腓肠神经和胫神经的传导速度，并且为了评估自主神经系统的功能，测试了R-R间期变异性和交感神经皮肤反应。在大多数患者中发现了感觉运动神经病变的症状和体征，其中约50% 有自主神经功能障碍。观察到年龄与R-R间期变异性之间呈负相关。未发现神经病变与肾病病程、肾衰竭病程及透析治疗之间存在关联。
