Alpherts W C, Vermeulen J, Franken M, Aldenkamp A P, van Veelen C W
Instituut voor Epilepsiebestrijding Meer en Bosch/De Cruquiushoeve, Psychologisch Laboratorium, Heemstede.
Ned Tijdschr Geneeskd. 1999 Jan 30;143(5):251-4.
To evaluate the long-term effects of epilepsy surgery on intelligence.
Prospective descriptive.
The group included 20 patients of the Instituut voor Epilepsiebestrijding, Heemstede, and the Epilepsiecentrum Kempenhaeghe, Heeze, the Netherlands, who suffered from medication-resistant epilepsy originating from the temporal lobe, in 9 patients from the left lobe (mean age: 33.1 years), in 11 from the right one (34.6 years). The epilepsy focus was removed surgically (Academic Hospital, Utrecht). The scores on the 'Wechsler adult intelligence scale' (WAIS) were determined before the operation and 6 months, 2 years and 6 years after operation.
The mean WAIS IQs before operation were: verbal IQ (VIQ): 111.8 and performance IQ (PIQ): 117.7 in the group treated on the left and VIQ: 113.5 and PIQ: 112.4 in the group treated on the right. The mean gains 6 years after operation were 0.8 and 2.6 VIQ-points and 8.7 and 8.5 PIQ-points respectively. In the patients operated on the left the difference between VIQ and PIQ was significant 2 and 6 years after operation. The increase in IQs remained within what could be expected in retests. Only for the VIQ of patients treated on the left was a smaller retest effect found.
These figures show that in the long term epilepsy surgery does not have an adverse outcome on the intelligence.
评估癫痫手术对智力的长期影响。
前瞻性描述性研究。
该组包括荷兰海姆斯泰德癫痫治疗研究所和埃泽癫痫中心的20名患者，他们患有源自颞叶的药物难治性癫痫，其中9名患者来自左侧颞叶（平均年龄：33.1岁），11名来自右侧颞叶（34.6岁）。癫痫病灶通过手术切除（乌得勒支学术医院）。在手术前以及术后6个月、2年和6年测定“韦氏成人智力量表”（WAIS）得分。
手术前，左侧治疗组的平均WAIS智商为：言语智商（VIQ）：111.8，操作智商（PIQ）：117.7；右侧治疗组的VIQ：113.5，PIQ：112.4。术后6年的平均增长分别为0.8和2.6个VIQ点以及8.7和8.5个PIQ点。在左侧接受手术的患者中，术后2年和6年VIQ与PIQ之间的差异显著。智商的提高仍在复测预期范围内。仅左侧治疗患者的VIQ发现较小的复测效应。
这些数据表明，从长期来看，癫痫手术对智力没有不良影响。
