Trivin F, Odievre M
Arch Fr Pediatr. 1976 Mar;33(3):293-304.
The main stages of bilirubin metabolism and the present state of neonatal hyperbilirubinemia are reviewed. The heterogeneity of substrates for bilirubin synthesis and the regulation of the heme-oxygenase activity are stressed. The importance of albumin for the bilirubin transport and the factors modifying this transport are studied. The detection of free bilirubin and reserve bilirubin binding capacity in neonatal jaundice is discussed as a method to estimate the risk of kernicterus. The induction of bilirubin glucuronyl transferase activity with some drugs and the phototherapy are effective in the treatment of hyperbilirubinemia; their values are discussed from the most recent reports.
本文综述了胆红素代谢的主要阶段以及新生儿高胆红素血症的现状。着重强调了胆红素合成底物的异质性以及血红素加氧酶活性的调节。研究了白蛋白在胆红素转运中的重要性以及影响该转运的因素。讨论了检测新生儿黄疸中游离胆红素和储备胆红素结合能力作为评估核黄疸风险的一种方法。某些药物诱导胆红素葡萄糖醛酸转移酶活性以及光疗在治疗高胆红素血症方面是有效的；根据最新报告对它们的价值进行了讨论。
