采用双重过滤血浆置换术成功治疗一名非血友病性因子Ⅷ抑制物患者。
Successful treatment of a non-haemophilic patient with inhibitor to factor VIII by double-filtration plasmapheresis.
作者信息
Sunagawa T, Uezu Y, Kadena K, Tokuyama K, Kinjo F, Saito A
机构信息
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
出版信息
Br J Haematol. 1999 Mar;104(3):465-7. doi: 10.1046/j.1365-2141.1999.01220.x.
Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs. In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few patients show resistance to immunosuppressive therapy. We describe a non-haemophilic elderly patient with acquired FVIII inhibitor who failed to respond to prednisolone. He was treated with double-filtration plasmapheresis (DFPP) which resulted in a very rapid reduction in inhibitor levels and resolution of symptoms.
在注射凝血因子VIII（FVIII）浓缩物后，3%至20%的甲型血友病患者会出现FVIII抑制剂。然而，非血友病患者中也有针对FVIII的自身抗体的报道。在这些患者中，FVIII抑制剂会自发消失或在免疫抑制治疗后减少。然而，少数患者对免疫抑制治疗有抵抗性。我们描述了一名患有获得性FVIII抑制剂的非血友病老年患者，其对泼尼松龙治疗无反应。他接受了双重滤过血浆置换术（DFPP），结果抑制剂水平迅速降低，症状得到缓解。
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