Livni E, Lapidoth M, Halevy S
Transplant Laboratory, Rabin Medical Center, Beilinson Campus, Petah Tiqva , Israel.
Acta Derm Venereol. 1999 Jan;79(1):18-22. doi: 10.1080/000155599750011633.
T-cells are involved in the pathogenesis of cutaneous drug reactions. T-cell phenotype and cytokine release pattern in rivo and in vitro might correlate with the type of immune response involved in cutaneous drug reactions. In vitro release of interferon-gamma and macrophage migration inhibition factor (MIF) from peripheral blood lymphocytes, following in vitro challenge with the suspected unmodified drugs, was studied in 12 patients with drug-induced urticaria and/or angioedema and in two group-matched controls. The occurrence of positive interferon-gamma and MIF responses was significantly higher in patients with drug-induced urticaria and/or angioedema than in controls. The sensitivity and specificity of the interferon-gamma test (50% and 92%, respectively) were similar to that of the MIF test (58% and 96%, respectively). Percentage agreement between both tests was 80.9 (kappa = 0.76). In vitro release of interferon-gamma and MIF in drug-induced urticaria and/or angioedema suggests a drug-specific immune response, and may implicate the drug as a possible inducer of the reaction.
T细胞参与皮肤药物反应的发病机制。体内和体外的T细胞表型及细胞因子释放模式可能与皮肤药物反应所涉及的免疫反应类型相关。在12例药物性荨麻疹和/或血管性水肿患者及两组匹配的对照中，研究了用疑似未修饰药物进行体外刺激后外周血淋巴细胞中γ干扰素和巨噬细胞移动抑制因子（MIF）的体外释放情况。药物性荨麻疹和/或血管性水肿患者中γ干扰素和MIF阳性反应的发生率显著高于对照组。γ干扰素试验的敏感性和特异性（分别为50%和92%）与MIF试验（分别为58%和96%）相似。两种试验之间的百分比一致性为80.9（kappa = 0.76）。药物性荨麻疹和/或血管性水肿中γ干扰素和MIF的体外释放提示存在药物特异性免疫反应，并且可能表明该药物是反应的可能诱导剂。
