Alameda F, Lloreta J, Ferrer M D, Corominas J M, Galitó E, Serrano S
Hospital del Mar-IMAS-IMIM, Autonomous University of Barcelona, Spain.
Ultrastruct Pathol. 1999 Jan-Feb;23(1):51-8. doi: 10.1080/019131299281842.
Clear cell meningioma (CCM) is a peculiar variant that differs from conventional meningioma in affecting younger patients, arising more often in spinal or cerebellopontine locations, and showing a higher recurrence rate. Classical meningothelial areas are scarce in these tumors and the differential diagnosis with other neoplasms, particularly metastatic carcinoma, is often difficult. We report a case of clear cell meningioma from the lumbosacral spine in which location, radiologic presentation, light microscopic appearance in initial sampling, and some of the ultrastructural findings were reminiscent of chordoma. The tumor cells were diffusely positive for vimentin and very focally positive for epithelial membrane antigen. Ultrastructural demonstration of interdigitating cell processes joined by numerous desmosomes confirmed the diagnosis of CCM.
透明细胞型脑膜瘤（CCM）是一种特殊的变异型，与传统脑膜瘤不同，它好发于年轻患者，更常发生于脊髓或桥小脑区，且复发率较高。这些肿瘤中典型的脑膜上皮区域少见，与其他肿瘤，尤其是转移癌的鉴别诊断往往很困难。我们报告一例来自腰骶部脊柱的透明细胞型脑膜瘤，其位置、影像学表现、初次取材的光镜表现以及一些超微结构发现均提示脊索瘤。肿瘤细胞波形蛋白弥漫阳性，上皮膜抗原局灶阳性。超微结构显示指状细胞突起由大量桥粒连接，确诊为透明细胞型脑膜瘤。
