Hough R E, Smith C M, Nakielny R A, Robinson M H, Jacubowski J, Lorigan P C, Hancock B W
Yorkshire Cancer Research Section of Clinical Oncology, Weston Park Hospital, Sheffield S10 2SJ, UK.
Int J Oncol. 1999 Apr;14(4):647-52. doi: 10.3892/ijo.14.4.647.
Primary intracerebral lymphoma is an uncommon presenting site for non-Hodgkin's lymphoma. The authors review 28 histopathologically confirmed, consecutive cases, presenting over a 15-year period. The cohort included 20 males and 8 females with a mean age at diagnosis of 54 years (range 27-75 years). Subtotal resection was performed in 8 patients. Radical whole brain irradiation was given to 27 patients. One patient was too unwell to receive treatment and quickly died. Three patients also had chemotherapy. Clinical remission was achieved in 19 patients. Of these, 9 relapsed after a median interval of 18 months. Nine patients (32% total cohort) are still alive and in remission after a median follow-up of 2 years and 10 months (range 11 months to 11 years and 5 months). Cause of death was intracerebral lymphoma in 13 of the 19 patients who died. Median survival was 12 months in this group (range 1 week to 4 years and 9 months). Actuarial 5-year survival for all patients was 19%. The prognosis for patients with primary intracerebral lymphoma treated with radiotherapy alone is poor.
原发性脑内淋巴瘤是非霍奇金淋巴瘤不常见的发病部位。作者回顾了15年间连续收治的28例经组织病理学确诊的病例。该队列包括20名男性和8名女性，诊断时的平均年龄为54岁（范围27 - 75岁）。8例患者接受了次全切除术。27例患者接受了全脑根治性放疗。1例患者病情太重无法接受治疗，很快死亡。3例患者也接受了化疗。19例患者实现了临床缓解。其中，9例在中位间隔18个月后复发。9例患者（占总队列的32%）在中位随访2年零10个月（范围11个月至11年零5个月）后仍存活且处于缓解状态。19例死亡患者中有13例死于脑内淋巴瘤。该组患者的中位生存期为12个月（范围1周 至4年零9个月）。所有患者的5年精算生存率为19%。单纯接受放疗的原发性脑内淋巴瘤患者预后较差。
