Tsuchida Y, Hayashi Y, Asami K, Yamamoto K, Yokoyama J, Mugishima H, Honna T, Mimaya J, Hara F, Sawada T, Matsumura T, Suita S, Sugimoto T, Kaneko M
Gunma Children's Medical Center, Hokkitsu, Seta-gun, Gunma 377-8577, Japan.
Int J Oncol. 1999 Apr;14(4):673-9. doi: 10.3892/ijo.14.4.673.
The efficacy of granisetron hydrochloride 20 microg/kg and 40 microg/kg were compared using a cross-over method to determine the optimal dose in children with solid tumors receiving high-dose chemotherapy. Granisetron controlled the onset of vomiting in 17 of 23 patients (73.9%) who were given 40 microg/kg of granisetron, while 8 of 21 patients (38.1%) were free of vomiting in the 20 microg/kg group. The average frequency of vomiting was 7.22 times in the 20 microg/kg dose versus 4.44 times in the 40 microg/kg dose. No safety problems were associated with either dose. The 40 microg/kg dose of granisetron appears to be more optimal.
采用交叉试验方法比较了20微克/千克和40微克/千克盐酸格拉司琼的疗效，以确定接受大剂量化疗的实体瘤患儿的最佳剂量。在接受40微克/千克格拉司琼的23例患者中，有17例（73.9%）呕吐发作得到控制，而在接受20微克/千克格拉司琼的21例患者中，有8例（38.1%）未出现呕吐。20微克/千克剂量组呕吐的平均次数为7.22次，而40微克/千克剂量组为4.44次。两种剂量均未出现安全问题。40微克/千克剂量的格拉司琼似乎更具优势。
