Hook S, Cheng P, Holloway J, Riley G, Sawyer G, Le Gros G, Beasley R
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New
Exp Clin Immunogenet. 1999;16(1):33-5. doi: 10.1159/000019094.
The Th2 cytokine interleukin 4 (IL-4) has been identified as having a central role in driving the inflammatory immune responses which are present in atopic airway disease. This study examined the distribution of two putative IL-4 promoter polymorphisms (-285 C-T and -81 A-G) in groups of patients with severe and moderate asthma, non-asthmatic atopy and control subjects. Neither polymorphism was identified in any of the samples tested. The data suggest that either the polymorphisms are present at very low frequencies or are artefacts of the B cell lines from which they were identified.
Th2细胞因子白细胞介素4（IL-4）已被确定在引发特应性气道疾病中存在的炎症性免疫反应方面发挥核心作用。本研究检测了两组重度和中度哮喘患者、非哮喘性特应症患者及对照受试者中两种假定的IL-4启动子多态性（-285 C-T和-81 A-G）的分布情况。在所检测的任何样本中均未发现这两种多态性。数据表明，要么这些多态性以极低频率存在，要么是从其中鉴定出它们的B细胞系的人为产物。
