Hamir A N, Lehmann B, Raju N, Ebel J G, Manzell K L, Rupprecht C E
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348, USA.
J Comp Pathol. 1999 Feb;120(2):147-54. doi: 10.1053/jcpa.1998.0261.
Four pairs of raccoons were treated orally with the following doses of lead acetate (mg/kg; 5 days/week, for 8 weeks): 0 (control), 1, 2 and 4. In the six experimental animals, this treatment produced dose-dependent increases in blood lead, without clinical signs or changes in haematological parameters. After 8 weeks, the liver and kidney of all lead-treated animals and the calvarium and radius of those receiving doses of 2 and 4 mg/kg contained elevated concentrations of lead. Acid-fast inclusions were observed by light and electron microscopy in the kidneys of all raccoons receiving the two highest doses and in one animal receiving the lowest dose. Hepatic acid-fast inclusions were seen in only one animal (dose 4 mg/kg). No inclusions were seen in osteoclasts of the radius. It is suggested that the findings, which support earlier observations that raccoons are fairly resistant to lead, may be of value in studying interactions between lead exposure and oral vaccination of wildlife against rabies.
给四对浣熊口服以下剂量的醋酸铅（毫克/千克；每周5天，共8周）：0（对照）、1、2和4。在这六只实验动物中，这种处理使血铅呈剂量依赖性增加，且无临床症状或血液学参数变化。8周后，所有接受铅处理的动物的肝脏和肾脏以及接受2毫克/千克和4毫克/千克剂量的动物的颅骨和桡骨中铅浓度升高。通过光学和电子显微镜在所有接受最高两个剂量的浣熊的肾脏以及一只接受最低剂量的动物的肾脏中观察到抗酸性包涵体。仅在一只动物（剂量4毫克/千克）的肝脏中发现抗酸性包涵体。在桡骨破骨细胞中未发现包涵体。有人认为，这些发现支持了早期关于浣熊对铅具有相当抗性的观察结果，可能对研究铅暴露与野生动物口服狂犬病疫苗之间的相互作用具有价值。
