通过微囊化重组细胞进行异源蛋白的体内递送。

The in vivo delivery of heterologous proteins by microencapsulated recombinant cells.

作者信息

Chang P L, Van Raamsdonk J M, Hortelano G, Barsoum S C, MacDonald N C, Stockley T L

机构信息

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

出版信息

Trends Biotechnol. 1999 Feb;17(2):78-83. doi: 10.1016/s0167-7799(98)01250-5.

DOI:10.1016/s0167-7799(98)01250-5

PMID:10087608

Abstract

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

摘要

重组细胞的微囊化是一种新型且可能具有成本效益的异源蛋白递送方法。一种经过基因改造以分泌任何所需蛋白质的“通用”细胞系，通过包裹在微囊中在免疫上受到保护，免受组织排斥。然后可以将微囊植入不同的受体中以在体内递送重组蛋白。