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[使用磷酸氟达拉滨(氟达拉滨)治疗对标准化疗耐药的慢性B细胞淋巴细胞白血病和非霍奇金淋巴瘤]

[The use of fludarabine phosphate (Fludara) to treat chronic B-cell lymphocytic leukemia and non-Hodgkin's lymphoma resistant to standard chemotherapy].

作者信息

Gershanovich M L, Zaritskiĭ A Iu, Medvedeva N V, Abdulkadyrov K M, Samuskevich I G, Beresneva I A

机构信息

Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St.Petersburg.

出版信息

Vopr Onkol. 1998;44(6):696-700.

Abstract

Following monochemotherapy with fludarabin phosphate (fludara), complete (18%), and partial remission (27%) with stabilization (45%) was recorded in patients with B-cell chronic lymphocytic leukemia, most of whom were resistant to alkylating cytostatic drugs and their combinations containing anthracyclines. Long-term remission was registered in patients with low and moderate grade non-Hodgkin's lymphoma, resistant to standard cytostatic treatment, due to the therapeutic synergism of fludara and cytosinarabinoside (FAVAMP).

摘要

在用磷酸氟达拉滨(氟达拉)进行单药化疗后,B细胞慢性淋巴细胞白血病患者出现了完全缓解(18%)、部分缓解(27%)以及病情稳定(45%),其中大多数患者对烷化剂类细胞毒性药物及其含蒽环类药物的联合方案耐药。对于低级别和中级别非霍奇金淋巴瘤患者,由于氟达拉滨和阿糖胞苷(FAVAMP)的治疗协同作用,在对标准细胞毒性治疗耐药的情况下,实现了长期缓解。

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