Reynolds P N, Feng M, Curiel D T
University of Alabama at Birmingham, Gene Therapy Center 35294, USA.
Mol Med Today. 1999 Jan;5(1):25-31. doi: 10.1016/s1357-4310(98)01378-1.
Gene therapy to correct defective genes requires efficient gene delivery and long-term gene expression. The vector systems currently available have not allowed the simultaneous provision of both of these goals. Several groups are now developing chimeric viral vector systems that incorporate the favorable attributes of two different viral vectors. These chimeric vectors might allow the goals for specific gene therapy applications to be realized.
纠正缺陷基因的基因疗法需要高效的基因传递和长期的基因表达。目前可用的载体系统还无法同时实现这两个目标。现在有几个研究小组正在开发嵌合病毒载体系统，该系统整合了两种不同病毒载体的有利特性。这些嵌合载体可能会使特定基因治疗应用的目标得以实现。
