Buznikov G A, Lauder J M
N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Neurosci Behav Physiol. 1999 Jan-Feb;29(1):11-21. doi: 10.1007/BF02461353.
The classical neurotransmitters (acetylcholine and biogenic monoamines) are multifunctional substances involved in intra- and intercellular signaling at all stages of ontogenesis in multicellular animals. A cyclical scheme is proposed to describe age-related changes in neurotransmitter functions at different stages of development from oocyte maturation to neuron formation. This may reflect not only the temporospatial organization of neurotransmitter processes, but also the origin of the functions of acetylcholine and biogenic monoamines from the protosynapses of the cleaved embryo to neuronal synapses.
经典神经递质（乙酰胆碱和生物源单胺）是多细胞动物个体发育各个阶段参与细胞内和细胞间信号传导的多功能物质。本文提出了一个循环模式，以描述从卵母细胞成熟到神经元形成的不同发育阶段神经递质功能的年龄相关变化。这不仅可能反映神经递质过程的时空组织，还可能反映从分裂胚胎的原始突触到神经元突触的乙酰胆碱和生物源单胺功能的起源。
