De Vita F, Orditura M, Auriemma A, Infusino S, Catalano G
Cattedra di Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale F. Magrassi, II Università di Napoli, Naples, Italy.
J Exp Clin Cancer Res. 1998 Dec;17(4):413-7.
To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean cytokines concentrations in patients were significantly higher than in the control population. Patients with metastatic disease had higher levels than those with undisseminated disease. Finally, in patients with tumor progression we observed an increase of cytokines serum levels. These results suggest that in NSCLC elevated serum levels of proinflammatory cytokines may have prognostic value being associated with a worse prognosis.
为评估促炎细胞因子血清浓度与非小细胞肺癌（NSCLC）预后之间的关系，我们检测了60例未经治疗的晚期NSCLC患者血清中肿瘤坏死因子-α（TNF-α）、白细胞介素-1-β（IL-1-β）和白细胞介素-6（IL-6）的水平。患者的细胞因子平均浓度显著高于对照组人群。有转移疾病的患者其细胞因子水平高于无播散疾病的患者。最后，在肿瘤进展的患者中，我们观察到细胞因子血清水平升高。这些结果表明，在NSCLC中，促炎细胞因子血清水平升高可能具有预后价值，与较差的预后相关。
