Nordlind K, Vahlquist A
Akademiska sjukhuset, Uppsala.
Lakartidningen. 1999 Feb 24;96(8):876-81.
Nowhere in the body are inflammatory reactions more apparent than in the skin. The inflammation may be beneficial, as in defence against tumours or infections, or inimical, as in allergy and psoriasis. The skin is a primary immunological organ which presents antigens to T cells, and produces many types of cytokines. The complex interplay between cells and mediators in immunologically induced skin diseases is beginning to be unveiled. Other new developments include improved immunosuppressive therapy and highly specific anti-inflammatory treatment that induces naturally occurring down-regulatory signals.
炎症反应在身体任何部位都没有在皮肤中表现得那么明显。炎症可能是有益的,如在抵御肿瘤或感染时;也可能是有害的,如在过敏和牛皮癣中。皮肤是一个主要的免疫器官,它将抗原呈递给T细胞,并产生多种细胞因子。免疫诱导性皮肤病中细胞与介质之间复杂的相互作用正开始被揭示出来。其他新进展包括改进的免疫抑制疗法和能诱导自然产生下调信号的高度特异性抗炎治疗。