Franks C R, Williams Y
Br J Cancer. 1976 Dec;34(6):641-4. doi: 10.1038/bjc.1976.225.
Peripheral lymphocyte counts were performed on 41 patients with advanced breast cancer, before starting treatment with oestrogens or androgens. Patients were seen at monthly intervals, and the response to treatment was independently assessed, using the criteria of the British Breast Group. In the patients treated with oestrogens and androgens, the successful responders were found to have significantly higher pre-treatment peripheral lymphocyte counts than the intermediate responders and failures. It is suggested that pre-treatment peripheral lymphocyte counts may have a prognostic value in assessing potential response to hormone therapy in patients with breast cancer.
在41例晚期乳腺癌患者开始使用雌激素或雄激素治疗前，进行外周淋巴细胞计数。患者每月复诊一次，并采用英国乳腺组的标准独立评估治疗反应。在用雌激素和雄激素治疗的患者中，发现治疗成功的患者治疗前外周淋巴细胞计数显著高于中度反应者和治疗失败者。提示治疗前外周淋巴细胞计数可能对评估乳腺癌患者激素治疗的潜在反应具有预后价值。
