生长抑素受体sst2A在人类风湿性滑膜中的免疫组织化学定位
Immunohistochemical localization of somatostatin receptor sst2A in human rheumatoid synovium.
作者信息
ten Bokum A M, Melief M J, Schonbrunn A, van der Ham F, Lindeman J, Hofland L J, Lamberts S W, van Hagen P M
机构信息
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
出版信息
J Rheumatol. 1999 Mar;26(3):532-5.
OBJECTIVE
To identify the somatostatin receptor-expressing cells in rheumatoid synovium using a recently developed antiserum directed against the somatostatin receptor subtype 2A (sst2A).
METHODS
We carried out immunohistochemical studies of synovial biopsies from 7 patients with rheumatoid arthritis (RA) and one non-RA patient, using a rabbit polyclonal antiserum directed against sst2A and monoclonal antibodies directed against phenotypic markers.
RESULTS
SSt2A was expressed by the endothelial cells of the synovial venules but also by a subset of synovial macrophages.
CONCLUSION
The identification of somatostatin receptors on macrophages, which are thought to be important effector cells in RA, may offer mechanistic insights into the potential therapeutic effect of somatostatin (analogs) in RA.
目的
使用一种最近开发的针对生长抑素受体亚型2A（sst2A）的抗血清，鉴定类风湿性滑膜中表达生长抑素受体的细胞。
方法
我们使用针对sst2A的兔多克隆抗血清和针对表型标志物的单克隆抗体，对7例类风湿性关节炎（RA）患者和1例非RA患者的滑膜活检组织进行了免疫组织化学研究。
结果
SSt2A在滑膜小静脉的内皮细胞中表达，也在一部分滑膜巨噬细胞中表达。
结论
巨噬细胞上生长抑素受体的鉴定，而巨噬细胞被认为是RA中重要的效应细胞，这可能为生长抑素（类似物）在RA中的潜在治疗作用提供机制上的见解。
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