Anyukhovsky E P, Sosunov E A, Gainullin R Z, Rosen M R
Laboratory of Heart Electrophysiology, Institute of Experimental Cardiology, Moscow, Russia.
J Cardiovasc Electrophysiol. 1999 Feb;10(2):244-60. doi: 10.1111/j.1540-8167.1999.tb00667.x.
A recent publication by us has been interpreted by some as arguing against the existence and importance of M cells. We suppose this is the reason we have been asked to write this "controversy." Regrettably for the controversy, neither our work nor we deny the existence of M cells. Rather, we have confirmed, conceivably ad nauseum, that M cells do exist and contribute importantly to the expression of electrical activity in the intact myocardium. What controversy there is relates to (1) whether there is an inhomogeneous transmural gradient for ventricular repolarization in normal hearts, and (2) why the electrophysiologic properties of different myocardial sites differ so markedly at the level of the isolated tissue and single cell and yet become so much more homogenous in the intact ventricle. These issues are addressed on the following pages.
我们最近发表的一篇文章被一些人解读为反对M细胞的存在及其重要性。我们认为这就是我们被要求撰写这篇“争议文章”的原因。遗憾的是，对于这场争议而言，我们的研究工作以及我们本人都没有否认M细胞的存在。相反，我们已经反复证实，M细胞确实存在，并且对完整心肌中电活动的表达起着重要作用。存在的争议涉及两个方面：（1）正常心脏中是否存在心室复极的跨壁不均匀梯度；（2）为什么在分离组织和单细胞水平上，不同心肌部位的电生理特性差异如此显著，而在完整心室中却变得更加均匀。以下各页将探讨这些问题。
