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视网膜色素变性中的铜代谢

Copper metabolism in retinitis pigmentosa.

作者信息

Gahlot D K, Khosla P K, Makashir P D, Vasuki K, Basu N

出版信息

Br J Ophthalmol. 1976 Nov;60(11):770-4. doi: 10.1136/bjo.60.11.770.

DOI:10.1136/bjo.60.11.770
PMID:1009056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042836/
Abstract

Clinically and electrophysiologically confirmed cases of primary retinitis pigmentosa have been investigated regarding their copper metabolic state. It is observed that these patients show a normal or near normal serum copper concentration, very low plasma caeruloplasmin concentration, and a very high copper urinary excretion. A similarity between this condition and hepatolenticular degeneration is drawn and it is suggested that retinitis pigmentosa may also be a condition caused by an inborn error of copper metabolism.

摘要

对临床和电生理确诊的原发性视网膜色素变性病例进行了铜代谢状态的研究。观察到这些患者血清铜浓度正常或接近正常，血浆铜蓝蛋白浓度极低，尿铜排泄量极高。有人将这种情况与肝豆状核变性进行了比较，并提出视网膜色素变性也可能是一种由先天性铜代谢缺陷引起的疾病。

相似文献

1
Copper metabolism in retinitis pigmentosa.视网膜色素变性中的铜代谢
Br J Ophthalmol. 1976 Nov;60(11):770-4. doi: 10.1136/bjo.60.11.770.
2
Clinical copper metabolism parameters in patients with retinitis pigmentosa and other tapeto-retinal degenerations.视网膜色素变性和其他毯层视网膜变性患者的临床铜代谢参数
Br J Ophthalmol. 1977 Sep;61(9):595-6. doi: 10.1136/bjo.61.9.595.
3
Copper metabolism in American retinitis pigmentosa patients.美国视网膜色素变性患者的铜代谢
Br J Ophthalmol. 1978 Mar;62(3):168-71. doi: 10.1136/bjo.62.3.168.
4
Copper metabolism in retinitis pigmentosa patients.视网膜色素变性患者的铜代谢
Br J Ophthalmol. 1981 Feb;65(2):127-30. doi: 10.1136/bjo.65.2.127.
5
[Changes in copper and zinc levels in the serum, erythrocytes and urine of patients with retinitis pigmentosa].[色素性视网膜炎患者血清、红细胞及尿液中铜和锌水平的变化]
Pediatr Pol. 1984 Mar;59(3):209-16.
6
[Copper and zinc metabolism in primary retinitis pigmentosa].[原发性视网膜色素变性中的铜和锌代谢]
Zhonghua Yan Ke Za Zhi. 1987 Mar;23(2):85-7.
7
Copper metabolism changes in pigmentary retinopathies and high myopia.色素性视网膜病变和高度近视中的铜代谢变化。
Metab Pediatr Ophthalmol. 1981;5(1):49-53.
8
Levels of zinc in plasma, erythrocytes, and hair, and levels of serum copper in patients with retinitis pigmentosa in Turkey.土耳其视网膜色素变性患者血浆、红细胞和头发中的锌水平以及血清铜水平。
Br J Ophthalmol. 1989 Jan;73(1):29-31. doi: 10.1136/bjo.73.1.29.
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Copper metabolism study in oculocutaneous albinism.
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Cu, Zn and SOD determination in patients with retinitis pigmentosa.视网膜色素变性患者铜、锌及超氧化物歧化酶的测定
Trans Ophthalmol Soc U K (1962). 1986;105 ( Pt 3):345-7.

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Case Report: The First Reported Concurrence of Wilson Disease and Bilateral Retinitis Pigmentosa.病例报告：首例威尔逊病与双侧视网膜色素变性并存的报告
Front Med (Lausanne). 2022 Apr 28;9:877752. doi: 10.3389/fmed.2022.877752. eCollection 2022.
3
Copper metabolism in retinitis pigmentosa patients.视网膜色素变性患者的铜代谢
Br J Ophthalmol. 1981 Feb;65(2):127-30. doi: 10.1136/bjo.65.2.127.
4
Absence of abnormal erythrocyte superoxide dismutase, copper, or zinc levels in patients with retinitis pigmentosa.视网膜色素变性患者红细胞超氧化物歧化酶、铜或锌水平无异常。
Br J Ophthalmol. 1982 Jul;66(7):417-21. doi: 10.1136/bjo.66.7.417.
5
Levels of zinc in plasma, erythrocytes, and hair, and levels of serum copper in patients with retinitis pigmentosa in Turkey.土耳其视网膜色素变性患者血浆、红细胞和头发中的锌水平以及血清铜水平。
Br J Ophthalmol. 1989 Jan;73(1):29-31. doi: 10.1136/bjo.73.1.29.
6
Clinical copper metabolism parameters in patients with retinitis pigmentosa and other tapeto-retinal degenerations.视网膜色素变性和其他毯层视网膜变性患者的临床铜代谢参数
Br J Ophthalmol. 1977 Sep;61(9):595-6. doi: 10.1136/bjo.61.9.595.
7
Copper metabolism in American retinitis pigmentosa patients.美国视网膜色素变性患者的铜代谢
Br J Ophthalmol. 1978 Mar;62(3):168-71. doi: 10.1136/bjo.62.3.168.

本文引用的文献

1
Micro-determination of copper in biological material.生物材料中铜的微量测定。
Biochem J. 1940 Sep;34(8-9):1202-8. doi: 10.1042/bj0341202.
2
The effects of B.A.L. in hepatolenticular degeneration.二巯基丙醇对肝豆状核变性的作用。
Brain. 1951 Mar;74(1):10-22. doi: 10.1093/brain/74.1.10.
3
On the copper content in urine in proteinuria.蛋白尿患者尿液中的铜含量
Scand J Clin Lab Invest. 1950;2(4):337-40. doi: 10.3109/00365515009056684.
4
The urinary excretion of copper and its concentration in the blood of normal human adults.正常成年人尿液中铜的排泄及其血液中的浓度。
J Clin Pathol. 1956 May;9(2):157-61. doi: 10.1136/jcp.9.2.157.
5
Studies on copper metabolism. XV. The excretion of copper by animals.
J Lab Clin Med. 1955 Nov;46(5):702-8.
6
Studies on copper metabolism. XIV. Copper, ceruloplasmin and oxidase activity in sera of normal human subjects, pregnant women, and patients with infection, hepatolenticular degeneration and the nephrotic syndrome.铜代谢研究。十四。正常人体、孕妇以及感染、肝豆状核变性和肾病综合征患者血清中的铜、铜蓝蛋白及氧化酶活性
J Clin Invest. 1955 Oct;34(10):1498-508. doi: 10.1172/JCI103201.
7
Studies on copper metabolism I. A method for the determination of copper in whole blood, red blood cells, and plasma.铜代谢研究I. 全血、红细胞和血浆中铜的测定方法。
J Biol Chem. 1952 May;196(1):209-20.
8
Electro-oculography in albinos.白化病患者的眼电图检查
Acta Ophthalmol (Copenh). 1974;52(2):220-4. doi: 10.1111/j.1755-3768.1974.tb00370.x.