Gamberini M R, Fortini M, Gilli G, Testa M R, De Sanctis V
Department of Pediatrics, S. Anna Hospital of Ferrara, Italy.
J Pediatr Endocrinol Metab. 1998;11 Suppl 3:867-9.
The incidence and prevalence of insulin-dependent diabetes mellitus (IDDM) and impaired glucose tolerance (IGT) were studied in a series of 273 patients with thalassaemia major followed in Ferrara from 1954 to 1998. It was found that the prevalence of glucose metabolism abnormalities has decreased and that the mean age of diagnosis has increased over the years. Risk factors associated with IDDM and IGT were lack of compliance with chelation therapy, iron overload and the presence of cirrhosis and severe fibrosis.
1954年至1998年期间，在费拉拉对273例重型地中海贫血患者进行了随访，研究了胰岛素依赖型糖尿病（IDDM）和糖耐量受损（IGT）的发病率和患病率。结果发现，多年来糖代谢异常的患病率有所下降，诊断的平均年龄有所增加。与IDDM和IGT相关的危险因素包括不遵守螯合疗法、铁过载以及存在肝硬化和严重纤维化。
