转移性黑色素瘤同步生物化疗相关的急性肿瘤溶解综合征：一例报告及文献复习
Acute tumor lysis syndrome associated with concurrent biochemotherapy of metastatic melanoma: a case report and review of the literature.
作者信息
Castro M P, VanAuken J, Spencer-Cisek P, Legha S, Sponzo R W
机构信息
Glens Falls Cancer Center, New York 12801, USA.
出版信息
Cancer. 1999 Mar 1;85(5):1055-9.
BACKGROUND
Treatment of solid tumors rarely has been associated with tumor lysis syndrome. However, to the authors' knowledge the clinical scenario has not been reported previously in melanoma patients.
METHODS
A patient with bulky metastatic melanoma was treated with concurrent biochemotherapy using interleukin-2, interferon-alpha, and a combination of cisplatin, vinblastine, and dacarbazine.
RESULTS
Within 24 hours of the initiation of treatment, brisk tumor lysis occurred and led to a fatal outcome.
CONCLUSIONS
Improvements in the treatment of solid tumors may increase the incidence of tumor lysis syndrome for tumors once believed to be marginally responsive. Oncologists should remain cognizant of this problem as more active regimens become available.
背景
实体瘤的治疗很少与肿瘤溶解综合征相关。然而，据作者所知，这种临床情况此前尚未在黑色素瘤患者中报道过。
方法
一名患有巨大转移性黑色素瘤的患者接受了白细胞介素-2、α干扰素以及顺铂、长春碱和达卡巴嗪联合的同步生物化疗。
结果
治疗开始后24小时内，迅速发生肿瘤溶解并导致致命结局。
结论
实体瘤治疗方法的改进可能会增加曾被认为反应轻微的肿瘤发生肿瘤溶解综合征的发生率。随着更多积极的治疗方案出现，肿瘤学家应继续关注这一问题。
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