Mock W L, Wang L
Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061, USA.
Biochem Biophys Res Commun. 1999 Apr 2;257(1):239-43. doi: 10.1006/bbrc.1999.0440.
Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of carboxypeptidase A by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(C3H4N2)2-4 coordination complexes, providing for the enzyme an anomalous profile of catalytic rate versus imidazole concentration.
