急性间歇性吗啡可增加大鼠脑内前强啡肽原和κ阿片受体mRNA水平。
Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain.
作者信息
Wang X M, Zhou Y, Spangler R, Ho A, Han J S, Kreek M J
机构信息
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10021, USA.
出版信息
Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):184-7. doi: 10.1016/s0169-328x(99)00021-2.
We determined the effects of morphine on mRNA levels for the opioid ligands preprodynorphin (PPD) and preproenkephalin (PPE) and the kappa opioid receptor (KOR). Rats received six injections of morphine (6.25 mg/kg/injection) every 2 h, and were sacrificed 30 min later. mRNA levels were measured in brain tissue after removal of the cortex, cerebellum and brainstem. There were increases in PPD and KOR mRNA levels (P<0.05 and P<0.005, respectively), with no alteration of PPE. These alterations in the kappa/dynorphin system may counter morphine-induced effects on the brain.
我们确定了吗啡对阿片样物质配体前强啡肽原（PPD）、前脑啡肽原（PPE）和κ阿片受体（KOR）mRNA水平的影响。大鼠每2小时接受6次吗啡注射（6.25毫克/千克/次），30分钟后处死。去除皮质、小脑和脑干后，测量脑组织中的mRNA水平。PPD和KOR的mRNA水平升高（分别为P<0.05和P<0.005），而PPE没有变化。κ/强啡肽系统的这些改变可能会抵消吗啡对大脑的诱导作用。
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