2-乙酰氨基-2-脱氧-D-吡喃葡萄糖苷甲基醚在强碱性离子交换树脂上的分离

The separation of methyl ethers of methyl 2-acetamido-2-deoxy-D-glucopyranosides on a strongly basic ion-exchange resin.

作者信息

Allen A K, Davies R C, Neuberger A

出版信息

Carbohydr Res. 1976 Nov;51(2):149-55. doi: 10.1016/s0008-6215(00)83322-4.

DOI:10.1016/s0008-6215(00)83322-4

Abstract

The methyl ethers of methyl 2-acetamido-2-deoxy-alpha- and -beta-D-glucopyranoside can be isolated on a preparative scale by chromatography on Dowex-1(HO-) resin. This procedure greatly simplifies the purification of methyl ethers, and has been used to isolate the methyl ethers produced by partial methylation of methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside. The separations are thought to depend on an ion-exchange process in which all the free hydroxyl groups are involved. It is concluded that the following acidity sequence holds: HO-4 greater than HO-3 greater than HO-6.

摘要

2-乙酰氨基-2-脱氧-α-和-β-D-吡喃葡萄糖苷甲酯的甲基醚可以通过在Dowex-1(HO-)树脂上进行色谱分离以制备规模得到。该方法极大地简化了甲基醚的纯化，并已用于分离由2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷甲酯部分甲基化产生的甲基醚。据认为，分离取决于一个离子交换过程，其中所有游离羟基都参与其中。得出的结论是，以下酸度顺序成立：HO-4大于HO-3大于HO-6。

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