人类恶性间皮瘤中的中间丝（10纳米）

Intermediate (10 nm) filaments in human malignant mesothelioma.

作者信息

Lehto V P, Virtanen I

出版信息

Virchows Arch B Cell Pathol. 1978 Oct 16;28(3):229-34. doi: 10.1007/BF02889072.

Abstract

Human malignant mesotheliomas were studied by electron microscopy. Three main types of cells were seen--submesothelial epithelioid cells, epithelial lining cells and fibroblast-like cells. In submesothelial epithelioid cells prominent arrays of intermediate (10 nm) filaments were often seen attached to plasma membrane, mitochondria, nuclei and concentric whorls of rough endoplasmic reticulum. The other types of cell found in the tumors, epithelial lining cells and fibroblast-like cells, lacked such distinct filaments. The intermediate filaments were especially abundant in cells with extensive whorling of endoplasmic reticulum. The association of intermediate filaments with such deranged cytoplasmic organization suggests that they play a role in the altered behavior of malignant cells.

摘要

通过电子显微镜对人类恶性间皮瘤进行了研究。观察到三种主要类型的细胞——间皮下皮样细胞、上皮衬里细胞和成纤维细胞样细胞。在间皮下皮样细胞中，常可见到突出的中间丝（10纳米）阵列附着于质膜、线粒体、细胞核及粗面内质网的同心环。肿瘤中发现的其他类型细胞，即上皮衬里细胞和成纤维细胞样细胞，缺乏这种明显的丝。中间丝在内质网广泛呈环的细胞中尤为丰富。中间丝与这种紊乱的细胞质结构的关联表明它们在恶性细胞行为改变中起作用。