Hagen T, Bartylla K, Piepgras U
Department of Neuroradiology, Saarland University Medical School, Homburg/Saar, Germany.
J Comput Assist Tomogr. 1999 Mar-Apr;23(2):257-64. doi: 10.1097/00004728-199903000-00015.
The purpose of this work was to investigate the validity of perfusion MRI in comparison with stable xenon CT for evaluating regional cerebral blood flow (rCBF).
The rCBF was measured by xenon CT and perfusion MRI within a 24 h interval in 10 patients (mean +/- SD age 63 +/- 10 years). For perfusion MRI, absolute values of rCBF were calculated based on the indicator dilution theory after injection of 0.1 mmol/kg of Gd-DTPA. Eight to 10 regions of interest (37 mm2) were located in the white and gray matter on the rCBF images for each of the 10 patients.
The mean +/- SD values of rCBF in gray matter were 48.5 +/- 14.1 ml/100 g/min measured by xenon CT and 52.2 +/- 16.4 ml/100 g/min measured by perfusion MRI. In the white matter, the rCBF was 22.6 +/- 9.1 ml/100 g/min by xenon CT and 27.4 +/- 6.8 ml/100 g/min by perfusion MRI. There was a good correlation of rCBF values between perfusion MRI and xenon CT (Pearson correlation coefficient 0.83; p < 0.0001).
Comparable to xenon CT, perfusion MRI provides relatively high resolution, quantitative local rCBF information coupled to MR anatomy.
本研究旨在探讨灌注磁共振成像（MRI）与稳定氙CT相比在评估局部脑血流量（rCBF）方面的有效性。
对10例患者（平均年龄±标准差为63±10岁）在24小时内分别用氙CT和灌注MRI测量rCBF。对于灌注MRI，在注射0.1 mmol/kg的钆-二乙三胺五乙酸（Gd-DTPA）后，根据指示剂稀释理论计算rCBF的绝对值。在10例患者的每例患者的rCBF图像上，在白质和灰质中定位8至10个感兴趣区（37平方毫米）。
灰质中rCBF的平均±标准差，用氙CT测量为48.5±14.1 ml/100 g/min，用灌注MRI测量为52.2±16.4 ml/100 g/min。在白质中，rCBF用氙CT测量为22.6±9.1 ml/100 g/min，用灌注MRI测量为27.4±6.8 ml/100 g/min。灌注MRI和氙CT之间的rCBF值具有良好的相关性（Pearson相关系数为0.83；p<0.0001）。
与氙CT相比，灌注MRI可提供分辨率相对较高的、与MR解剖结构相关的定量局部rCBF信息。
