Blüml S, Tan J, Harris K, Adatia N, Karme A, Sproull T, Ross B
Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
J Comput Assist Tomogr. 1999 Mar-Apr;23(2):272-5. doi: 10.1097/00004728-199903000-00017.
Quantitative proton MR spectroscopy (MRS) and proton-decoupled phosphorus MRS were applied in the parietal cortex of 13 schizophrenic subjects (11 drug-treated and 2 neuroleptic-naive) and 15 normal control subjects. Significantly increased concentrations of glycerophosphorylcholine (1.18 +/- 0.16 vs. 0.93 +/- 0.14 mmol/kg brain; p < 0.001), glycerophosphoethanolomine (0.70 +/- 0.19 vs. 0.59 +/- 0.07 mmol/kg; p < 0.04), and phosphocreatine (3.73 +/- 0.39 vs. 3.41 +/- 0.13 mmol/kg; p < 0.007), but no differences in N-acetylaspartate, total creatine, or myo-inositol, were determined in treated schizophrenic subjects. Identical abnormalities were found in two neuroleptic-naive patients. These results provide new evidence of disordered cerebral membrane and high energy phosphate metabolism in schizophrenia.
对13名精神分裂症患者（11名接受药物治疗，2名未接受过抗精神病药物治疗）及15名正常对照者的顶叶皮质进行了定量质子磁共振波谱分析（MRS）和质子去耦联磷磁共振波谱分析。结果显示，接受治疗的精神分裂症患者甘油磷酸胆碱浓度显著升高（分别为1.18±0.16与0.93±0.14 mmol/kg脑；p<0.001）、甘油磷酰乙醇胺浓度显著升高（分别为0.70±0.19与0.59±0.07 mmol/kg；p<0.04）、磷酸肌酸浓度显著升高（分别为3.73±0.39与3.41±0.13 mmol/kg；p<0.007），但N-乙酰天门冬氨酸、总肌酸或肌醇无差异。两名未接受过抗精神病药物治疗的患者也发现了同样的异常。这些结果为精神分裂症患者存在脑膜紊乱和高能磷酸代谢提供了新证据。
