Durak I, Yalçin S, Burak Cimen M Y, Büyükkoçak S, Kaçmaz M, Oztürk H S
Department of Biochemistry, Faculty of Medicine, Ankara University, Turkey.
J Toxicol Environ Health A. 1999 Mar 26;56(6):373-8. doi: 10.1080/009841099157962.
In this study, activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzymes were measured in the erythrocytes, and levels of thiobarbituric acid-reactive substances (TBARS) and antioxidant potential (AOP) values were measured in both erythrocyte and plasma samples from smokerS and nonsmokers. No significant differences were observed in erythrocyte parameters, serum triglycerides, and total cholesterol. AOP was significantly lower and TBARS level higher in the plasma samples from smokers compared with those of nonsmokers. Results suggest that smoking causes no impairment in the enzymatic antioxidant defense system and does not lead to oxidant stress in the erythrocytes, possibly because these cells have potent antioxidant defense capacity.
在本研究中，测定了吸烟者和非吸烟者红细胞中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性，并测定了红细胞和血浆样本中硫代巴比妥酸反应性物质（TBARS）的水平和抗氧化潜力（AOP）值。在红细胞参数、血清甘油三酯和总胆固醇方面未观察到显著差异。与非吸烟者相比，吸烟者血浆样本中的AOP显著降低，TBARS水平升高。结果表明，吸烟不会损害酶促抗氧化防御系统，也不会导致红细胞中的氧化应激，这可能是因为这些细胞具有强大的抗氧化防御能力。
