Ganter K, Bongartz D, Hesse A
Department of Urology, University of Bonn, Germany.
Urology. 1999 Mar;53(3):492-5. doi: 10.1016/s0090-4295(98)00581-0.
To evaluate the relation of Tamm-Horsfall protein (THP) and citrate, both potent actors in the urinary stone forming process.
Quantitative determination of THP in calcium oxalate (CaOx) stone-forming patients and healthy subjects was carried out according to the enzyme-linked immunosorbent assay method.
THP excretion in 24-hour urine samples of CaOx stone-forming patients was significantly reduced compared with healthy subjects. A significant correlation exists between the concentration of THP and citrate in the stone-forming group, as well as in the group of healthy subjects, and for the 24-hour excretion, this correlation persists in the group of CaOx stone-forming patients.
Decreased THP and citrate excretions were found in CaOx stone-forming patients. They indicate a tubular dysfunction of the distal section.
评估Tamm-Horsfall蛋白（THP）和柠檬酸盐这两种在尿路结石形成过程中起重要作用的物质之间的关系。
采用酶联免疫吸附测定法对草酸钙（CaOx）结石形成患者和健康受试者的THP进行定量测定。
与健康受试者相比，CaOx结石形成患者24小时尿液样本中的THP排泄量显著降低。在结石形成组以及健康受试者组中，THP浓度与柠檬酸盐之间存在显著相关性，对于24小时排泄量，这种相关性在CaOx结石形成患者组中依然存在。
在CaOx结石形成患者中发现THP和柠檬酸盐排泄减少。它们表明远端肾小管功能障碍。
