Pillai M R, Samuel G, Banerjee S, Mathew B, Sarma H D, Jurisson S
Radiopharmaceuticals Section, Isotope Division, Bhabha Atomic Research Centre, Mumbai, India.
Nucl Med Biol. 1999 Jan;26(1):69-77. doi: 10.1016/s0969-8051(98)00051-1.
Novel polydentate amine-pyrrole and amine-thiophene ligands were synthesized and characterized by 1H and 13C NMR spectroscopy. Radiochemical studies with 99mTc were carried out at 0.1-100 microM of technetium. Complexation yields were estimated from thin layer chromatography (TLC), paper electrophoresis, and solvent extraction studies. The 99mTc complexes formed were found to be neutral and lipophilic. Complexes with the corresponding imine-ligands were formed in lower yields. Biodistribution studies of the 99mTc complexes of these ligands showed no significant uptake in brain or heart, and the clearance was mainly through the hepatobiliary system.
合成了新型多齿胺 - 吡咯和胺 - 噻吩配体，并通过1H和13C核磁共振光谱对其进行了表征。使用99mTc在0.1 - 100微摩尔的锝浓度下进行了放射化学研究。通过薄层色谱（TLC）、纸电泳和溶剂萃取研究估计络合产率。发现形成的99mTc络合物呈中性且具有亲脂性。与相应亚胺配体形成的络合物产率较低。这些配体的99mTc络合物的生物分布研究表明，在脑或心脏中没有明显摄取，清除主要通过肝胆系统。
