Buznikov G A, Rakic L
N. K. Kol'tsov Institute of Developmental Biology of the Russian Acad. Sci., Moscow, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Oct;84(10):1038-48.
Agonists of nicotinic acetylcholine receptors (nAChR) nicotine and 1-acetyl-4-methylpiperazine do not act on the early sea urchin embryogenesis but evoke calcium shock in both oocytes and early embryos under certain conditions. Many nAChR ligands protect both oocytes and embryos against this shock. There seem to exist putative nAChR on the cell surface of the early sea urchin oocytes and early embryos. Pre-nervous acetylcholine seems to be functionally coupled via these receptors with the second messengers, endogenous activators of the protein kinase C.
烟碱型乙酰胆碱受体（nAChR）的激动剂尼古丁和1-乙酰基-4-甲基哌嗪对海胆早期胚胎发育无作用，但在某些条件下可在卵母细胞和早期胚胎中引发钙休克。许多nAChR配体可保护卵母细胞和胚胎免受这种休克的影响。海胆早期卵母细胞和早期胚胎的细胞表面似乎存在推定的nAChR。神经节前乙酰胆碱似乎通过这些受体与第二信使、蛋白激酶C的内源性激活剂功能偶联。
